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背景与目的：RhoGD12是RhoGDP解离抑制因子(RhoGDI)家族的主要成员之一,它能够有效的抑制膀胱癌细胞的转移。研究证明,RhoGD12在细胞凋亡过程中,其N端19位置被caspase3酶切形成D19LyGDI短肽,并转移至细胞核或线粒体,进而参与相关信号传递的传递。
人RhoGDI2的N端缺失突变体诱导膀胱癌细胞凋亡的研究
【摘 要】
：
背景与目的：RhoGD12是RhoGDP解离抑制因子(RhoGDI)家族的主要成员之一,它能够有效的抑制膀胱癌细胞的转移。研究证明,RhoGD12在细胞凋亡过程中,其N端19位置被caspase3酶切
【机 构】
：
华东理工大学鲁华生物技术研究所,上海200231
【出 处】
：
2013年第四届全国“跨学科蛋白质研究”学术讨论会
【发表日期】
：
2013年10期
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