【摘 要】
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Cancer stem cells (CSCs) have received considerable attention.Accumulating evidence suggests that CSCs are responsible for tumor initiation and progression, drug resistance, and metastasis.Development
【机 构】
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WuXi Apptec (Shanghai) Co., Ltd.China
论文部分内容阅读
Cancer stem cells (CSCs) have received considerable attention.Accumulating evidence suggests that CSCs are responsible for tumor initiation and progression, drug resistance, and metastasis.Development of novel compounds targeting CSC populations is becoming important for eradicating CSCs in heterogeneous tumor masses in order to cure the cancer.The history of CSC biology will be reviewed, and controversial term and definition in the field will be addressed.Moreover, we will share our experience in isolating CSCs, establishing CSC-enriching cell lines under serumfree conditions, and validating their CSC properties.Furthermore, how to develop CSC-relevant tumor models for novel target discovery and drug tests will be discussed by presenting some of our studies as examples.
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