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To observe the changes of miRNA expression profiles in the brain of aging rats,and their relationship with the expression of learning and memory related genes,and the intervention effect of Reinforcing Kidney and Nourishing Qi herbs.24 months old rats were used as the aging model and were randomly divided into old group,Zuogui pill group,Yiqi Congming decoction group,mixture group and antagonist group,and 5 months old rats as youth group.