【摘 要】
：
Neural cell adhesion molecule(NCAM)deficiency induces the expression of tumor necrosis factor-α(TNF-α),thereby leading to insulin resistance and impaired adipogenesis of mesenchymal stem cells(MSCs).H
【机 构】
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School of Life Science and Technology,Xinxiang Medical University,Xinxiang,Henan 453003,China
【出 处】
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中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议
论文部分内容阅读
Neural cell adhesion molecule(NCAM)deficiency induces the expression of tumor necrosis factor-α(TNF-α),thereby leading to insulin resistance and impaired adipogenesis of mesenchymal stem cells(MSCs).However,the regulation mechanism of TNF-α by NCAM in MSCs remains elusive.Here,we investigated the relationship between NCAM,TNF-α,and stress signaling pathways,including AMPK,p38,and JNK.In NCAM-deficient MSCs,AMPK and p38 signaling pathways were persistently activated,accompanied by elevated levels of reactive oxygen species(ROS).
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