Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：july1126

【摘要】

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【作者】

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Xi-Juan Liu Wen-Bo Zeng Fei Zhao Min-Hua Luo

【机构】

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State Key Laboratory of Virology,CAS Center for Excellence in Brain Science and Intelligence Technol

【出处】

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中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

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2018年10期

【关键词】

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HCMV IE1 Hes1 E3 ubiquitin ligase

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　　Congenital human cytomegalovirus(HCMV)infection is the leading cause of central nervous system mal-development in new born worldwide,but the mechanisms underlying these disorders remain to be illuminated.Our previous work has shown HCMV infection dysregulate the Notch signaling pathway in human neural progenitor cells(NPCs).Hes1,the transcriptional regulator Hairy and Enhancer of Split 1,an important downstream effector of Notch signaling governing NPC fate and fetal brain development.

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Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin

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