【摘 要】
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Cardiac regenerative therapy, by replenishing Iost cardiomyocytes and blood vessels, holds the promise to change the treatment paradigm for heart failure and post-infarction cardiac dysfunction.The re
【机 构】
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Regenerative Medicine Innovation Team AstraZeneca R & D Molndal Sweden
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Cardiac regenerative therapy, by replenishing Iost cardiomyocytes and blood vessels, holds the promise to change the treatment paradigm for heart failure and post-infarction cardiac dysfunction.The recent demonstration of new cardiomyocyte formation and existence of endogenous cardiac stem/progenitor cells in human adult heart has engendered great interest in developing pharmacological strategies to augment the potential of mammalian heart to regenerate in situ.Researchers at AstraZeneca are taking various approaches such as network/pathway analysis and phenotypic screening to identify molecules that activate endogenous stem/progenitor cells, induce proliferation of cardiomyocytes, or directly reprogram cardiac fibroblasts.Ill discuss various molecular approaches to cardiac regeneration and describe our research at AstraZeneca in discovering and developing regenerative therapeutics for the treatment of heart diseases.
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