• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. RGDC functionalized and hydroxycamptothecin-encapsulated magnetic nanohybrids for integrin avβ3-targ

RGDC functionalized and hydroxycamptothecin-encapsulated magnetic nanohybrids for integrin avβ3-targ

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：zzw441884878
【摘 要】
：
The combination of organic polymers and inorganic magnetic nanoparticles is interesting for controlled drug delivery [1].Our previous study has shown that hydroxycamptothecin (HCPT)-loaded magnetic na
【作 者】
：
Guobin Ding Yan Wang Wenbin Xu Yafan Li Jie Yang Yi Guo Li Xu 
【机 构】
：
Key laboratory for Molecular Enzymology and Engineering,the Ministry of Education,College of Life Sc
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
【发表日期】
：
2014年6期
【关键词】
：
RGDC integrin targeting magnetic nanohybrids antitumor efficacy anti-cell-migrat 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
　　The combination of organic polymers and inorganic magnetic nanoparticles is interesting for controlled drug delivery [1].Our previous study has shown that hydroxycamptothecin (HCPT)-loaded magnetic nanovehicles display effective antitumor efficacy [2].Herein,RGDC (arginine-glycineaspartic acid-cysteine) tetrapeptide functionalized and HCPT-encapsulated magnetic nanohybrids (RFHEMNs) were fabricated by co-encapsulating superparamagnetic Fe3O4 nanoparticles and HCPT into maleimide-terminated poly (ethylene glycol)-poly(D,L-lactide-co-glycolide) (Mal-PEG-PLGA)copolymer micelles,followed by covalently conjugating RGDC to the surface of the micelles (Fig.1).
其他文献
Polyelectrolyte complexes of poly[(2-dimethylmino) ethyl methacrylate]/chondroitin sulfate obtained
Poly((2-dimethylamino) ethyl methacrylate) (PDMAEMA) is thermo-responsive with LCST in 32 -53 ℃ in aqueous media [1].Chondroitin sulfate (CS) is a important biopolymer with applications as biomaterial
会议
PDMAEMAchondroitin sulfatepolyelectrolyte complexesreleasecytotoxicity
Encapsulation of doxorubicin within lactobionic acid-modified multifunctional poly(amidoamine) dendr
Current anticancer drugs used in the clinic suffer trom problems such as poor water solubility,rapid clearance,and nonspecific distribution in the normal tissue.Recent advances in dendrimer nanotechno
会议
dendrimersdoxorubicinPEGylationencapsulationtargeted cancer therapy
Pullulan-modified spray-dried powders for pulmonary drug delivery
The drug delivery to the lungs has attracted dramatically increasing attentions for the treatment of local and systemic diseases.Dry powder inhalers (DPI) offer the advantages of propellant-free,avoid
会议
pullulanspray-dryingpulmonary deliverysalbutamol sulfate
Controlled cyclic drug release based on chemomechanical gels
With advances in biomaterials,various novel artificial gels with capability to respond to stimuli (e.g.,temperature,light,force,pH) have emerged with great potential applications in drug delivery [1].
会议
chemomechanicsfunctional gelschemical reactioncontrollability analysis
Preparation and investigation of smart hydrogels of thiolated dextran and miR-145
Dextran is one of the FDA-approved natural polymers employed in medicines.In this study,we prepared dextran based polymer networks crosslinked by disulfide bonds,which are reduced in response to the r
会议
dextranmiR-145hydrogeldisulfide bonds
Targeted delivery of doxorubicin by lactobionic acid-modified laponite to hepatocarcinoma cells
Doxorubicin (DOX) is one of the most generally used chemotherapeutic drugs in antitumor applications.However,the severe side effect of DOX to normal tissues limits its dosage in treatment and reduces
会议
doxorubicinlaponitelactobionic acidtargeted drug deliveryhepatocarcinoma cel
pH and thermo dual-responsive polyaspartamide derivatives by click chemistry for drug delivery
Polymeric micelles have recently received great attention as a promising vehicle for drug delivery.Generally,both the water-insoluble polymer and the hydrophobic drug need to be dissolved in a suitabl
会议
pH-responsivethermo-responsivedrug deliverypolyaspartamide derivatives
Polymer vesicles assembled from ALG-g-PNIPAM and β-cyclodextrin through inclusion complexation for d
Polymer vesicles prepared from self-assembly of amphiphilie block or graft copolymers have been extensively studied for their potential applications in drug delivery and biological fields [1].The stru
会议
stimuli-sensitivity5-fluorouracilpolymer vesiclesdrug releaseALG-g-PNIPAM
Controlled release of cell sheet by saccharide and temperature dual-responsive hydrogel layer
By using thermo-responsive cell culture substrate,intact cell monolayers can be released spontaneously as a result of thermo-induced surface changing from hydrophobic to hydrophilic,thus this method h
会议
cell sheetcontrolled releasecell adhesionsaccharide-responsivethermo-respons
Camptothecin-conjugated biodegradable prodrug micelles for theranostic near-infrared fluorescent ima
Camptothecin(CPT) has shown significant antitumor activity in a broad spectrum of human malignancies.However,its use is hampered by rapid metabolism,short plasma half-life,and low selectivity towards
会议
camptothecinreduction-sensitiveIR-820prodrug micelles