【摘 要】
：
Isoforms are alternatively spliced forms of mRNA that are transcribed from the same gene but differ in the exons that are included in the mRNA transcript.This greatly increases the diversity of protei
【机 构】
：
The Jackson Laboratory for Genomic Medicine,USA
【出 处】
：
2016年国际树突状细胞研讨会(The 14th International Symposium on Dendriti
论文部分内容阅读
Isoforms are alternatively spliced forms of mRNA that are transcribed from the same gene but differ in the exons that are included in the mRNA transcript.This greatly increases the diversity of proteins translated from a single gene and it is estimated that the~23,000 human genes might generate >100,000 isoforms.Until now,tools to study isoforms have been very limiting.
其他文献
T cells receive a multitude of signals upon their activation by APC.While most of these signals are well described,little is known how each of these signals work together to control the response magni
Clec9A(DNGR1)is a dead cell recognition receptor on the surface of the XCR1+,cDC1 DC subtype(CD8+DC lineage in mice,BDCA3+DC in humans).Antibodies against Clec9A can be used to efficiently target anti
Econdary lymphoid organs(SLO)are the primary locations for initiation of immune responses.During embryonic lymphogenesis,lymphoid tissue-inducer cells(LTi)mediate the initial development of these stru
Despite their great success,we understand little about how effective vaccines stimulate protective immune responses.Two recent developments promise to yield such understanding:the appreciation of the
Macrophages represent a diverse set of phagocytic cells distributed in the whole body.They play a central role in a variety of biological events including host defence against pathogens,tissue remodel
In contrast to conventional T cells that recognize peptides on MHC proteins,CD1 molecules present lipid antigens to T lymphocytes.The abundant expression of CD1a hallmarks Langerhans cells in the skin
We study the human system to address fundamental questions in the context of the immune response to different classes of antigens,including microbial pathogens and self-antigens,to gain insights into
Systemic Lupus Erythematosus(SLE)is a systemic autoimmune disease characterized by a breakdown of tolerance to nuclear antigens and the development of DNA and RNA-containing immune complexes(IC).Genom
Plasmacytoid dendritic cells(pDC)are major producers of type Ⅰ interferons(IFN-I)in response to recognition of pathogen-derived nucleic acid molecules by endosomal toll-like receptors.Involvement of p
Dendritic cells(DCs)and macrophages play important roles in maintaining intestinal homeostasis.However,the molecular mechanisms that regulate the differentiation and responses of intestinal DCs and ma