【摘 要】
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In contrast to conventional T cells that recognize peptides on MHC proteins,CD1 molecules present lipid antigens to T lymphocytes.The abundant expression of CD1a hallmarks Langerhans cells in the skin
【机 构】
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Program in Cellular and Molecular Medicine,Boston Children's Hospital,Department of Microbiology an
【出 处】
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2016年国际树突状细胞研讨会(The 14th International Symposium on Dendriti
论文部分内容阅读
In contrast to conventional T cells that recognize peptides on MHC proteins,CD1 molecules present lipid antigens to T lymphocytes.The abundant expression of CD1a hallmarks Langerhans cells in the skin,a subtype of dendritic cell(DC)with antigen-presenting functions.CD1a can bind and display a broad spectrum of lipid antigens derived from exogenous sources,such as bacteria,or host origin.The intricate immune system of the skin is critically involved in responses to extrinsic insults like allergens,as well as in autoimmune diseases,such as psoriasis.
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