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In this work,a novel drug delivery approach to enhance tumor penetration and accumulation via the midway pickup of therapeutic nanoparticles by tumor-associated macrophages(TAMs)en route toward tumor hypoxia was developed.The nanoparticle carriers equipped with high selective affinity with macrophages were first attained from the self-assembly of poly(lactic acid-co-glycolic acid)-grafted hyaluronic acid(HA-g-PLGA)together with an anticancer drug,SN38,in aqueous phase.