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Nanotechnology is increasingly used in drug delivery.The use of nucleic acids to engineer well-defined,fully programmable,self-assembling nanoparticles has established the emerging fields of RNA nanotechnology.By constructing nanoscaffolds out of nucleic acids,scientists can precisely incorporate various functional moieties such as short interfering RNAs(siRNAs),aptamers,small molecules and proteins for various specific biomedical applications.This talk will focus on our recent achievements in the field of therapeutic RNA nanotechnology.