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DNA hydroxylation catalyzed by Tetdioxygenases occurs abundantly in embryonic stem cells and neurons in mammals.However.its biological function in vivo is largely unknown.Here we demonstrate that Tetl plays an important role in regulating neural progenitor cell proliferation in adult mouse brain.Mice lacking Tetl exhibit impaired hippocampal neurogenesis associated with poor learning and memory.The mutant mice also exhibit DNA hypermethylation and down-regulation of genesrelated to the proliferation of neural progenitor cells in the adult hippocampus.