【摘 要】
：
To evaluate whether HPV genotyping for the selected oncogenic HPV types can improve the efficacy ofHPV DNA testing in predicting CIN2/3 in women with the mi
【机 构】
：
Department of Pathology The University of Texas M.D.Anderson Cancer Center USA
【出 处】
：
BIT Life Sciences' 1st Annual World Cancer Congess-2008(
论文部分内容阅读
To evaluate whether HPV genotyping for the selected oncogenic HPV types can improve the efficacy ofHPV DNA testing in predicting CIN2/3 in women with the mildly abnormal Pap results, we compared HPV DNA testing and HPV genotyping for the eight oncogenic types (16, 18, 31, 33, 35, 45, 52 and 58) in Pap specimens with abnormal results (HSIL, 20 cases; LSIL, 42 cases; ASC-US, 94 cases) and follow-up biopsies.Using consensus primermediated PCR assays, HPV DNA was detected in 90% (18/20) of HSIL, 95% (40/42) of LSIL and 64% (60/94) of ASC-US cases.HPV DNA positivity was significantly associated with CIN 2/3/carcinoma (P<0.001) in women with ASC-US, but not in women with LSIL (P =0.52).OfHPV DNA positive specimens, the eight oncogenic HPV types were detected in 83% of HSIL cases (15/18), 53% of LSIL cases (21/40), and 47% of ASC-US cases (28/60).
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