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Virotherapy using tumor-selective viruses is becoming an increasingly realistic approach to the treatment of human cancer.Newcastle disease virus (NDV) is among the most promising natural oncolytic viruses.While its wild-type strains are lethally infectious in birds, it is virtually non-pathogenic in humans.Sporadic observations and smallscale clinical studies have been demonstrating oncolytic effects of NDV vaccines in certain patients with therapy resistant tumors (e.g.glioblastoma, colorectal cancer, melanoma).The aim of our research has been to analyze the presently unclear mechanisms of NDV oncolysis using cultured tumor cells.An attenuated NDV strain designated MTH-68/H was used to infect the PC 12 rat phaeochromocytoma cell line as well as various human tumor cell lines.