High-frequency generation of fertile transgenic mice from imprinted genes engineered androgenetic ha

来源 :The 7th Guangzhou International Conference on Stem Cell and | 被引量 : 0次 | 上传用户：ccwawa

【摘要】

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【作者】

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Yufang Liu Guang Liu Meili Zhang Lihong Sun Yue Huang

【机构】

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State Key Laboratory of Medical Molecular Biology,Department of Medical Genetics,Institute of Basic

【出处】

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The 7th Guangzhou International Conference on Stem Cell and

【发表日期】

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2014年5期

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Recently,androgenetic haploid embryonic stem cells (AG-haESCs) have been established from mouse androgenetic blastocysts.Fertile mice have been obtained from injection of AG-haESCs into mature oocytes indicating that they can substitute sperm cells.It also provides a new approach for producing genetically modified mice rapidly.

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High-frequency generation of fertile transgenic mice from imprinted genes engineered androgenetic ha

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