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We mainly depend on our vision and audition abilities to perceive the real world.Vision dominates our spatial perception,and audition determines our temporal perception.Superior colliculus (SC) is the primary multi-sensory integration region in our brain.In this proposed research,in vivo extracellular and intracellular recordings on SC neurons that are responsive to both visual and auditory stimuli have been made to study the temporal integration of these two mode sensory inputs.It would also be of an interest to examine whether a brief of temporally-associated visual and auditory inputs may result in an enhancement in the SC neurons response to either modal sensory input through the short-term and long-term plasticity.Our basic findings showed the spike-timing-dependent plasticity (STDP) after paired audiovisual inputs in SC bimodal neurons.These findings can be very likely to provide a synaptic (cellular) mechanism for the occurrence of those astonishing interaction cross different modalities in the psychophysical tests,such as the visualauditory illusion and lag adaptation.