Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-Heptose

来源 :中国生物化学与分子生物学会2019年全国学术会议 | 被引量 : 0次 | 上传用户：bfxj8812

【摘要】

：

Immune recognition of pathogen-associated molecular patterns(PAMPs)by pattern recognition receptors often activates proinflammatory NF-kappaB signalling.

【作者】

：

Ping Zhou Yang She Na Dong Peng Li Huabin He Alessio Borio Qingcui Wu Shan Lu Xiaojun Ding Yong Cao Yue Xu Wenqing Gao Mengqiu Dong Jingjin Ding Da-Cheng Wang Alla Zamyatina Feng Shao

【机构】

：

National Institute of Biological Sciences,Beijing,102206,China

【出处】

：

中国生物化学与分子生物学会2019年全国学术会议

【发表日期】

：

2019年10期

【关键词】

：

innate immunity bacterial infection ALPK1 ADP-heptose

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Immune recognition of pathogen-associated molecular patterns(PAMPs)by pattern recognition receptors often activates proinflammatory NF-kappaB signalling.

其他文献

Protein lysine de-2-hyroxyisobutyrylation by CobB in prokaryotes

The novel post-translational modification,lysine 2-hydroxyisobutyrylation(Khib),has recently been thought to be an evolutionarily conserved histone mark.

会议

Post-translational modificationLysine 2-hydroxyisobutyrylationEnzymeCobBBioc

33-kDa annexin A3 isoform promotes HCC and its knockdown suppresses tumorigenesis and malignancy via

Hepatocellular carcinoma(HCC)is the third leading cause of most common cancer-related deaths due to its higher metastasis,recurrence and chemoresistance.

会议

HCC33-kDa ANXA3tumorigenesischemo-resistanceapoptosis

抑制Sirt2-Atg4B(Acetylation)-autophagy通路增敏索拉非尼抗肝癌细胞的效应及机制研究

索拉非尼作为FDA批准的首个肝癌分子靶向药物，其有效性和安全性得到广泛认可，但是也有相当一部分接受索拉非尼治疗的患者，不但没有确切的疗效，反而增加由此带来的副作用和沉重的经济负担。如何抑制肝癌细胞索拉非尼耐药的发生，提高其治疗效果，逐渐成为近年来人们关注的热点。

会议

肝癌ATG4BSIRT2索拉非尼乙酰化

Coordinated regulation on transcription of nirA operon via NtcA and NtcB in Anabaena sp.PCC7120

Cyanobacteria are prokaryotes,also known as “blue-green algae”,which can execute photosynthesis and thus play an important role in the early formation of the Earth′s atmosphere.

会议

coordinated regulationNtcANtcBtranscription activation

The inhibitory effect of 17β-estradiol on triglyceride synthesis is dependent on ERα,not ERβ in skel

The aim of the study was to examine the inhibitory effects and the related mechanisms of 17β-estradiol(E2)on triglyceride synthesis and insulin resistance in skeletal muscle tissues and cells.

会议

estrogenfatty acid metabolismovariectomyskeletal muscleestrogen receptor

CRKL suppression decreases the proliferation,invasion and imatinib resistance of CML cells

BCR-ABL kinase activation triggers the downstream signaling molecules including phosphoinositide 3-kinase(PI3K)/Akt,FAK/Src,STAT5 and c-MYC.

会议

CMLCRKLproliferationmigrationinvasionapoptosis

N-糖链在肿瘤干细胞中的功能和意义

糖链是继核酸、多肽蛋白质后的第三条重要的生命分子链，而细胞内至少超过50％的蛋白质都是有糖链修饰的。糖链参与了包括细胞识别、细胞分化、发育、信号转导、免疫应答等各种重要生命活动。在肿瘤等人类现代重要疾病发生、发展中均伴随着蛋白质糖基化异常的发生，而糖基化异常调控肿瘤细胞恶性行为，并成为临床诊断和治疗的靶点。

会议

肿瘤干细胞CD133蛋白N-糖基化微环境

FAM129A overexpression promotes ccRCC clinical progression by enhancing patient's TNM stage and

Clear cell renal cell carcinoma(ccRCC)is the most aggressive RCC subtype.It is characterized with high rates of local invasion and metastasis,resistances to chemotherapy and radiotherapy.

会议

ccRCCFAM129ADevelopmentProgression

Sulfatide inhibits m6A methylation of MTF1 mRNA by interfering the m6A writer complex formation

Metal responsive transcription factor 1(MTF1)is a zinc dependent transcription factor which is involved in the regulation of intracellular signaling pathways.

会议

MTF1sulfatideHCCm6A methylationm6A writer complex

阿尔茨海默病外周血脂肪酸组成及代谢的变化

为了探明脂肪酸组成及代谢与阿尔茨海默病(AD)发病的关系，本研究对比分析了正常老年人(正常组)和AD患者(AD组)血清脂肪酸成分、脂肪酸代谢相关分子等的变化。按照AD诊断标准及排除标准筛选研究对象(AD组和正常组各30例)，空腹抽取外周静脉血，分离血清及单个核细胞用于实验。

会议

阿尔茨海默病脂肪酸组成脂肪酸β-氧化PPAR α

Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-Heptose

其他学术论文