N-糖链在肿瘤干细胞中的功能和意义

来源 :中国生物化学与分子生物学会2019年全国学术会议 | 被引量 : 0次 | 上传用户：wuzhi1979

【摘要】

：

糖链是继核酸、多肽蛋白质后的第三条重要的生命分子链，而细胞内至少超过50％的蛋白质都是有糖链修饰的。糖链参与了包括细胞识别、细胞分化、发育、信号转导、免疫应答等各种重要生命活动。在肿瘤等人类现代重要疾病发生、发展中均伴随着蛋白质糖基化异常的发生，而糖基化异常调控肿瘤细胞恶性行为，并成为临床诊断和治疗的靶点。

【作者】

：

梁紫微江建海

【机构】

：

复旦大学基础医学院卫生部糖复合物重点实验室,上海,200032

【出处】

：

中国生物化学与分子生物学会2019年全国学术会议

【发表日期】

：

2019年10期

【关键词】

：

肿瘤干细胞 CD133蛋白 N-糖基化微环境

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N-糖链在肿瘤干细胞中的功能和意义

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