Hyaluronic acid-based polymeric nanoparticles for targeting delivery of paclitaxel

来源 :2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会 | 被引量 : 0次 | 上传用户：ccysshucc

【摘要】

：

Aims:Based on the self-assembled properties of amphiphilic polymers and HA-mediated tumor targeting,amphiphilic hyaluronic acid (HA)-based derivative was developed as a carrier of paclitaxel (PTX) to

【作者】

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Jing Yao Li Zhang Jianping Zhou Hongpan Liu

【机构】

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Department of Pharmaceutics,China Pharmaceutical University,24 Tongjiaxiang,Nanjing 210009,China;Sta

【出处】

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2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

【发表日期】

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2012年10期

【关键词】

：

Hyaluronic acid Polymeric nanoparticles Tumor targeting Paclitaxel

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　　Aims:Based on the self-assembled properties of amphiphilic polymers and HA-mediated tumor targeting,amphiphilic hyaluronic acid (HA)-based derivative was developed as a carrier of paclitaxel (PTX) to improve the solubility of PTX and facilitate its tumor targeting delivery.Methods:PTX-loaded polymeric nanoparticles were prepared by the dialysis method.The effect of degree of substitution (DS) of hydrophobic section in polymers on drug loading,entrapment efficiency and particles size were investigated.The in vivo drug release was also evaluated.In addition,confocal microscopy was used to internalize the intracellular location ofnanoparticles.

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Hyaluronic acid-based polymeric nanoparticles for targeting delivery of paclitaxel

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