Somatostatin receptor-mediated tumor-targeting drug delivery using octreotide-PEG-paclitaxel conjuga

来源 :2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会 | 被引量 : 0次 | 上传用户：lfzmj

【摘要】

：

【作者】

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Meirong Huo Qinnv Zhu Yao Liu Jianping Zhou

【机构】

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Department of Pharmaceutics,China Pharmaceutical University,No.24 Tongjiaxiang,Nanjing 210009,China

【出处】

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2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

【发表日期】

：

2012年10期

【关键词】

：

octreotide somatostatin receptors prodrug polyethene glycol pacliatxel tumor tar

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　　Aims:A novel ligend-PEG-drug conjugate,octreotide-polyethene glycol-paclitaxel (OCT-PEG-PTX) was developed for efficient cancer therapy.Method:The ligand OCT was first conjugated to the carboxyl group of PEG by EDC reaction (OCT-PEG)and then the paclitaxel was conjugated to OCT-PEG by using succinic anhydride as a spacer (OCT-PEG-PTX).Non-targeted prodrug,PEG-PTX,was also synthesized as control.The chemical structures and physicochemical properties were characterized indetail.

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Somatostatin receptor-mediated tumor-targeting drug delivery using octreotide-PEG-paclitaxel conjuga

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