论文部分内容阅读
(Pro)renin receptor (PRR), a newly discovered component of the renin-angiotensin system (RAS), is viewed as a potential regulator of tissues RAS in light of its capability of binding renin and prorenin to increase their catalytic activity.Within the kidney, PRR expression is predominantly expressed in the intercalated cells of the CD where its expression is induced by AngⅡ.The goal of our study was to investigate the mechanism of how AngⅡ activated PRR in the CD cells and further explore the functional implication of this phenomenon.