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Hypertension and vascular dysfunction result in the increased release of endothelium-derived contracting factors (EDCFs), whose identity is poorly defined.We found that endothelial cyclooxygenase (COX)-2 can generate EDCFs and identified the possible EDCF candidate.Endothelium-dependent contractions were triggered by acetylcholine following inhibition of nitric oxide production and they were abolished by COX-2 but not COX-1 inhibitors or by TP receptor antagonists.