【摘 要】
：
ClC-3 chloride channel, plays an important role in the regulation of cell volume, proliferation and apoptosis.Preadipocytes of type 2 diabetes show a tendency to enhanced apoptosis.We hypothesized tha
【机 构】
：
中山大学中山医学院药理学教研室及心脑血管研究中心,广州,5100801 加拿大多伦多大学医学院外科
【出 处】
：
第九届海峡两岸心血管科学研讨会暨首届台湾南部国际心脑血管科学研讨会
论文部分内容阅读
ClC-3 chloride channel, plays an important role in the regulation of cell volume, proliferation and apoptosis.Preadipocytes of type 2 diabetes show a tendency to enhanced apoptosis.We hypothesized that there is a relation between ClC-3 and insulin resistance, and one underlying mechanism may be associated with the modulation of free fatty acid-induced preadipocyte apoptosis by ClC-3.Compared with the wild-type T2DM models, ClC-3 knockout T2DM mice displayed an improvement in insulin resistance, as evidenced by the significant decrease in homeostatic model assessment of insulin resistance (HOMA-IR).
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