Sitagliptin在高血压中上调胰高血糖素样肽-1受体的表达

来源 :第九届海峡两岸心血管科学研讨会暨首届台湾南部国际心脑血管科学研讨会 | 被引量 : 0次 | 上传用户：a20090907

【摘要】

：

目的:我们前期研究表明胰高血糖素样肽-1受体(GLP-1R)在高血压中表达下调,而高选择性二肽基肽酶Ⅳ抑制剂磷酸西他列汀(sitagliptin)能够恢复其表达,本研究目的是阐明相关的机制.方法:采用sitagliptin(10 mg.kg-1.d-1)给予自发性高血压大鼠SHR和正常血压对照组大鼠WKY灌胃2周,应用微血管张力测定仪检测血管舒张功能,通过Western blot检测蛋白的表达情况

【作者】

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刘利梅刘建徐晓健田小雨黄永德高远生黄聿

【机构】

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北京大学医学部生理与病理生理学系,北京,100191;香港中文大学生物医学学院,香港香港中文大学

【出处】

：

第九届海峡两岸心血管科学研讨会暨首届台湾南部国际心脑血管科学研讨会

【发表日期】

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2013年4期

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Sitagliptin在高血压中上调胰高血糖素样肽-1受体的表达

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