【摘 要】
：
目的:缺氧诱导的冠状动脉痉挛是导致心绞痛发生的一个重要原因.研究发现缺氧可以激活PI3K/Akt信号通路该通路在血管平滑肌的张力调节中起重要做用.本研究试图明确PI3K/Akt信号通路是否介导了缺氧诱导的猪冠状动脉痉挛,以及临床上常用的心绞痛治疗药物硝酸甘油是否可以通过调节PI3K/Akt从而改善冠状动脉痉挛.
【机 构】
：
北京大学医学部 生理学与病理生理学系,北京,中国 100191 北京大学医学部 生理学与病理生理学
【出 处】
：
第九届海峡两岸心血管科学研讨会暨首届台湾南部国际心脑血管科学研讨会
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目的:缺氧诱导的冠状动脉痉挛是导致心绞痛发生的一个重要原因.研究发现缺氧可以激活PI3K/Akt信号通路该通路在血管平滑肌的张力调节中起重要做用.本研究试图明确PI3K/Akt信号通路是否介导了缺氧诱导的猪冠状动脉痉挛,以及临床上常用的心绞痛治疗药物硝酸甘油是否可以通过调节PI3K/Akt从而改善冠状动脉痉挛.
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