【摘 要】
：
Background-5 adenosine monophosphate-activated protein kinase (AMPK) has been shown to interact with peroxisome proliferator-activated receptor delta (PPARδ) to induce gene expression synergistically
【机 构】
：
Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences, The Chinese University
【出 处】
：
第九届海峡两岸心血管科学研讨会暨首届台湾南部国际心脑血管科学研讨会
论文部分内容阅读
Background-5 adenosine monophosphate-activated protein kinase (AMPK) has been shown to interact with peroxisome proliferator-activated receptor delta (PPARδ) to induce gene expression synergistically and activation of AMPK inhibits endoplasmic reticulum (ER) stress.We aim to investigate whether PPARδ is an important mediator for the vascular benefits of anti-diabetic drug metformin (AMPK activator) in ameliorating ER stress and endothelial dysfunction in high-fat diet-induced obese (DIO) mice.
其他文献
Background and aims: Hepatocyte apoptosis is a central feature of many liver diseases, leading to liver inflammation and fibrosis.In this study, we first screened potential drugs inhibiting hepatic st
MicroRNAs play an important role in many cardiovascular diseases through modulation of gene expression at the post transcriptional level.This study was performed to identify a role of microRNA-16(miR-
近年來高壓氧治療已普遍應用於腦血管的疾病包括一氧化碳中毒,腦中風、腦外傷、脊髓損傷、心臟衰竭、低血糖、溺水、上吊等導致之腦缺氧,以及突發性耳聾或失明等.另外長期糖尿病和心臟血管疾病之周邊血管動脈阻塞導致下肢足部潰瘍有接受高壓氧治療亦有良好的效果.
Apocynum venetum, also called luobuma, is a shrub growing widely in the middle to northwestern region of China.Its leaves are generally used and commercialized as herbal tea or folk health drink for t
Purpose: We sought to assess whether heat-induced autophagy, apoptosis and cell damage in H9c2 cells can be affected by pre-inducing HSP70 (heat shock protein 70).Materials and methods: Cell viability
A clinical hallmark of hypertension is impairment of the cardiac vagal baroreflex, which maintains stable blood pressure and heart rate under physiological conditions.There is also evidence that oxida
Objective: We sought to assess the effect of therapeutic hypothermia on the autophagy that occurred in ischemia-reperfusion (IR) H9c2 cardiomyocytes.Methods: In control studies, the H9c2 cells at a de
Vascular function, characterized by endothelium-dependent relaxation (EDR), declines with age.A reduced bioavailability of vascular nitric oxide (NO), resulting from less NO production and more oxidat
Vascular endothelial growth factor (VEGF), in addition to its essential role in the processes of vascularization and angiogenesis, exerts direct effects on neural cells in the central nervous system.T
Purpose: Recent studies have implicated the human cytomegalovirus (HCMV) as a possible pathogen for causing hypertension.We aimed to study the association between HCMV infection and hypertension in th