PHOSPHORYLATION OF 532-THREONINE IN CLC-3 CL CHANNEL IS REQUIRED FOR ANGIOTENSINII-INDUCED CEREBROVA

来源 :第九届海峡两岸心血管科学研讨会暨首届台湾南部国际心脑血管科学研讨会 | 被引量 : 0次 | 上传用户：dsq223

【摘要】

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【作者】

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马明明刘芸汤勇波周家国吕晓飞关永源

【机构】

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中山大学中山医学院心血管药理研究中心

【出处】

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第九届海峡两岸心血管科学研讨会暨首届台湾南部国际心脑血管科学研讨会

【发表日期】

：

2013年4期

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Background: Vascular remodeling is a predominantly feature in hypertension, which relates to the process of vascular smooth muscle cell (VSMC) proliferation and migration.Previous studies have shown that ClC-3 volume-regulated Cl-channel is required for cerebrovascular remodeling in hypertensive rats.Moreover, Angiotensin Ⅱ could activate the volume-regulate chloride current (Icl,vol) in rabbit cardiac myocyte.In this study, we investigate the modulating mechanism of Angiotension Ⅱ-activated ICl,vol in mouse basilar artery smooth muscle cells (BASMCs) and the its role in cerebrovascular remodeling during hypertension.

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PHOSPHORYLATION OF 532-THREONINE IN CLC-3 CL CHANNEL IS REQUIRED FOR ANGIOTENSINII-INDUCED CEREBROVA

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