Novel TPGS based paclitaxel prodrug to overcome multidrug resistance of cancer cells

来源 :International Conference on Nanoscience & Technology,China 2 | 被引量 : 0次 | 上传用户：qiuzhizhedetiantang

【摘要】

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【作者】

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Yuling Bao Yuanyuan Guo Dan Li Bolin Chen Songwei Tan Zhiping Zhang

【机构】

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Tongji School of Pharmacy 2National Engineering Research Center for Nanomedicine,Tongji Medical Coll

【出处】

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International Conference on Nanoscience & Technology,China 2

【发表日期】

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2013年3期

【关键词】

：

Vitamin E TPGS paclitaxel multidrug resistance prodrug

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　　A simple Paclitaxel (PTX) prodrug based on TPGS and disulfide bond (TPGS-S-S-PTX) was synthesized by a two step esterification and its ability to overcome multidrug resistance (MDR) was investigated.This prodrug can be quickly cleaved after endocytosis by tumor cells to cause release of the active drug and consequent cancer cell cytotoxicity.

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Novel TPGS based paclitaxel prodrug to overcome multidrug resistance of cancer cells

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