【摘 要】
：
目的:比较高血压前期氯沙坦[20mg/ (kg·d)]和氨氯地平[10mg/ (kg·d)]治疗对卒中易感型自发性高血压大鼠(SHRSP)血压和脑卒中的影响.方法:4周龄雄性卒中易感型自发性高血压大鼠(SHRSP)随机分为3组,分别接受氯沙坦[SHRSP-Los组:20mg/ (kg·d)]、氨氯地平[SHRSP-Aml组:10mg/ (kg·d)]和安慰剂(SHRSP-Veh组)灌胃治疗6周,每
【出 处】
：
第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int
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目的:比较高血压前期氯沙坦[20mg/ (kg·d)]和氨氯地平[10mg/ (kg·d)]治疗对卒中易感型自发性高血压大鼠(SHRSP)血压和脑卒中的影响.方法:4周龄雄性卒中易感型自发性高血压大鼠(SHRSP)随机分为3组,分别接受氯沙坦[SHRSP-Los组:20mg/ (kg·d)]、氨氯地平[SHRSP-Aml组:10mg/ (kg·d)]和安慰剂(SHRSP-Veh组)灌胃治疗6周,每组24只,以性别周龄匹配Wistar京都种大鼠(WKY) 24只作为正常对照,停药后随访至40周.尾套法测量大鼠收缩压,记录脑卒中临床表现评分,放射免疫法检测血浆和脑皮质Ang Ⅱ和Aldo水平,免疫印迹法检测脑组织AT1R和AT2R蛋白表达水平.
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