长期血浆内皮素-1水平升高对异丙肾上腺素慢性致室性心律失常作用的影响

来源 :第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int | 被引量 : 0次 | 上传用户：wuhaoxust

【摘要】

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【作者】

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刘韬秦牧黄从新

【机构】

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武汉大学人民医院心血管病研究所

【出处】

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第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int

【发表日期】

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2013年2期

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目的:探讨长期血浆内皮素1(ET-1)水平升高对异丙肾上腺素(ISO)慢性致室性心律失常(VA)作用的影响.方法:雄性新西兰大耳兔60只,随机分为对照组(CTL组)、血浆ET-1升高组(ET-1组)、ISO组及ET-1+ISO组,每组15只.所有动物连续14天经耳缘静脉注射药物,其中ET-1组按10μ g/ (kg·d)剂量注射ET-1、ISO组按300 μ g/ (kg·d)剂量注射ISO、ET-1+ISO组同时注射ET-1与ISO(剂量与每天次数同前)及CTL组注射0.9％生理盐水1 ml/ (kg·d).所有动物完成药物注射7天后,在整体心脏Langendorff灌流条件下行离体电生理研究,分别记录和测量左室前游离壁(LAF)心外膜(Epi)单相动作电位(MAP)、有效不应期(VERP),并构建动作电位恢复性(APDR)曲线.对所有离体心脏于LAF处,行程控增频电刺激以观察动作电位时程(APD)电交替的发生;给予Burst快速电刺激用以进行VA的诱发.

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