OBJECTIVE The aim of the study was to explore genetic and environmental factors related to PD and association of SLC6A4 polymorphism with obsessive-compulsive personality disorder (OCPD).
Objective Major Depression(MD) is a heterogeneous disease and the precise aetiology is still unknown.The neuronal plasticity disorder is now considered to be one of the depression causes.Animal experi
Objectives Neuregulin-1 (NRG1) is implicated in the etiology or neuropathology of various psychiatric diseases such as schizophrenia and major depression,although its biological contribution to the in
Lithium,a direct inhibitor of glycogen synthase kinase 3 (GSK-3),has been widely prescribed mood stabilizer in treatment of bipolar disorder.Evidence suggests that lithium affects monocytic cells,whic
Objectives Bipolar disorder is a devastating illness that is characterized by cycling periods of mania and depression.Conversing lines of evidences indicate that mood disorders,including bipolar disor
Objectives Several postmortem studies have noted decreased expression of genes responsible for synaptic proteins in the prefrontal cortex (PFC) and other regions,suggesting impairment or reduction in
Objectives The alteration of hippocampal plasticity has been proposed to play a critical role in both the pathophysiology and the treatment of depression.In this study,the ability of different classes
Background The efficacy and safety of olanzapine monotherapy are evaluated in Japanese patients from a larger,global study of bipolar depression.
Objectives Mammalian target ofrapamycin (mTOR) is a protein kinase involved in the regulation of translation initiation and protein synthesis required for synaptic plasticity.Recent studies suggest th
目的 研究布南色林片单次给药后的人体药代动力学.方法 经广州市脑科医院伦理委员会审批通过,招募30例健康志愿者并分为3组,每组10人,男女各半,分别单次口服4 mg、8 mg和12 mg布南色林片后,采集0、0.25、0.5、0.75、1、1.5、2、3、4、6、8、12、24、36、48和60 h内动态血标本,采用HPLC-MS/MS测定血浆中布南色林的浓度,最后用DAS 3.2.4软件对试验数