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Objectives Several postmortem studies have noted decreased expression of genes responsible for synaptic proteins in the prefrontal cortex (PFC) and other regions,suggesting impairment or reduction in synaptic connectivity in schizophrenia.Moreover,antipsychotic drugs have been suggested to regulate synaptic transmission and structure.In this study,we investigate the effects of typical antipsyehotic drug,haloperidol and atypical antipsychotic drugs olanzapine and aripiprazole,on the expression of synaptic-associated proteins in the frontal cortex of rats subjected to immobilization stress.