伴有吸烟史的COPD患者HHIP基因多态性与罹患肺癌风险关系的研究

来源 :2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议 | 被引量 : 0次 | 上传用户：jettey

【摘要】

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【作者】

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王海涛张舒许靖蔡峰范艳红李挺生淑红付佑辉池峰周晨

【机构】

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上海中医药大学附属第七人民医院

【出处】

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2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议

【发表日期】

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2016年4期

【关键词】

：

COPD 肺癌基因多态性

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　　目的探讨HHIP基因(Hedgehog-interacting protein,HHIP)多态性与中国汉族人群中COPD患者发生肺癌风险的相关性。方法采用连接酶检测反应法(ligase detection reaction,LDR)的方法对465例COPD合并肺癌患者和207例单侧COPD患者HHIP基因的多态性位点rs1489758、rs1489759、rs10519717、rs13131837、rs1492820、rs7689420进行多态性分析。结果 HHIP基因的多态性位点rs1489758、rs1489759、rs10519717、rs13131837、rs1492820、rs7689420在2组对象中的基因型频率分布无统计学差异。结论本研究未发现HHIP基因的6个多态性位点与中国汉族COPD患者的肺癌发病风险有明确相关性。

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伴有吸烟史的COPD患者HHIP基因多态性与罹患肺癌风险关系的研究

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