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GABA receptor allosterism

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：jklgfdjligjregjmreji
【摘 要】
：
The two major classes of γ-aminobutyric acid (GABA) receptors are designated GABAA and GABAB.Whereas the GABAA receptor is a pentameric, ligand-gated ion channel, the GABAB site is a heterodimeric, G
【作 者】
：
S J ENNA 
【机 构】
：
Departments of Physiology and of Pharmacology,University of Kansas Medical School,Kansas City,Kansas
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
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论文部分内容阅读
The two major classes of γ-aminobutyric acid (GABA) receptors are designated GABAA and GABAB.Whereas the GABAA receptor is a pentameric, ligand-gated ion channel, the GABAB site is a heterodimeric, G protein-coupled receptor (GPCR).Both were initially characterized using orthosteric agents, such as muscimol and bicuculline for GABAA and baclofen for GABAB.After the discovery that benzodiazepines interact allosterically with the GABAA site, attention turned to determining whether other agents ad in a similar manner.
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