结构分辨率与蛋白质的功能理解水通道蛋白的故事

来源 :第四届全国冷冻电子显微学与结构生物学专题研讨会 | 被引量 : 0次 | 上传用户：kobeantoni198774

【摘要】

：

电子探测器技术的新发展使得冷冻电镜方法成为大分子量的蛋白质及复合体结构测定一个重要手段.与通常情况的x-光晶体学不同,冷冻电镜可以得到不同的分辨率和空间尺度的三维结

【作者】

：

隋海心

【出处】

：

第四届全国冷冻电子显微学与结构生物学专题研讨会

【发表日期】

：

2015年6期

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电子探测器技术的新发展使得冷冻电镜方法成为大分子量的蛋白质及复合体结构测定一个重要手段.与通常情况的x-光晶体学不同,冷冻电镜可以得到不同的分辨率和空间尺度的三维结构图.不同分辨率下的三维结构图对于蛋白质功能机理的理解是有影响的.本报告以多年前的一个膜蛋白结构和功能研究故事为实例,讨论一下当年基于不同分辨率的结构图对于蛋白质的功能机理的理解差别.

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结构分辨率与蛋白质的功能理解水通道蛋白的故事

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