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Detection of subtle microcalcifications in digital breast tomosynthesis(DBT)is a challenging task because of the large,noisy DBT volume.It is important to enhance the contrast-to-noise ratio(CNR)of microcalcifications in DBT reconstruction.Most regularization methods depend on local gradient and may treat the ill-defined margins or subtle spiculations of masses and subtle microcalcifications as noise because of their small gradient.The authors developed a new multiscale bilateral filtering regularization method for the simultaneous algebraic reconstruction technique to improve the CNR of microcalcifications without compromising the quality of masses.