Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the b

来源 :中国睡眠研究会第7届全国学术年会暨2012金陵国际睡眠医学论坛 | 被引量 : 0次 | 上传用户：pingli_lp

【摘要】

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【出处】

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中国睡眠研究会第7届全国学术年会暨2012金陵国际睡眠医学论坛

【发表日期】

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2012年8期

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　　Magnolol, an active ingredient of the bark of Magnolia officinalis, has been reported to exert potent anti-epileptic effects via the GABAA receptor.The receptor also mediates sleep in humans and animals.The aim of this study was to determine whether magnolol could modulate sleep behaviors by recording EEG and electromyogram in mice.The results showed that magnolol administered i.p.at a dose of 5 or 25 mg/kg could significantly shorten the sleep latency, increase the amount of non-rapid eye movement (non-REM, NREM) and rapid eye movement (REM) sleep for 3 h after administration with an increase in the number of NREM and REM sleep episodes.

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Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the b

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