Hypothalamic Regulation of Sleep-wake Cycle,from Basic Research to Drug Discovery

来源 :中国睡眠研究会第7届全国学术年会暨2012金陵国际睡眠医学论坛 | 被引量 : 0次 | 上传用户：pearl12345

【摘要】

：

【出处】

：

中国睡眠研究会第7届全国学术年会暨2012金陵国际睡眠医学论坛

【发表日期】

：

2012年8期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Difficulties formulating comprehensive approaches to treat sleep-related diseases persist because the physiological mechanisms underlying sleep-wake regulation remain unclear.We employed gene-manipulated mice in combination with neurophysiology, neurochemistry, pharmacology and molecular biology approaches to clarify the molecular mechanisms of hypothalamic sleep-wake regulation.

其他文献

PK凝胶安全药理学试验研究

会议

注射用参麦皂苷急性毒性试验

会议

静脉注射黏菌素对小鼠神经行为功能及形态学影响

会议

淫羊藿素比格狗口服给药270天毒代动力学研究

会议

Activation of GABAA receptor or inhibition of dopamine D2 receptor improves sleep disturbance in mou

First night effect (FNE), a well-known phenomenon in human, is characterized by longer sleep latency and decreased total sleep time, which results from a subjects lack of adaptation to the unfamiliar

会议

Abnormal amygdala connectivity in patients with primary insomnia: Evidence from resting state fMRI

Background: Neurobiological mechanisms underlying insomnia are poorly understood.Previous findings indicated that dysfunction of the emotional circuit might contribute to the neurobiological mechanism

会议

Adenosin A2AR-expressing Neurons in the Core of Mouse Nucleus Accumbens: Morphology,Neurochemical Pr

Objectives The morphology, neurochemical properties and axon projections of the neurons expressing adenosine A2A receptor (A2AR) in the mouse nucleus accumbens (NAc) were investigated to understand th

会议

Effects of Neu-P11 on sleep disturbance under a neuropathic pain-like condition in partial sciatic n

Insomnia is a common problem for people with neuropathic pain.Therapies that not only reduce pain, but also improve sleep can provide multiple benefits without the risk of increased side effects for s

会议

Neu-P11sleep disturbanceneuropathic painnaloxone

Effect of electroacupuncture on menopausal insomnia in rats

Electroacupuncture (EA) has been used to treat menopausal insomnia due to its significant efficacy in clinic.Because there is a lack of animal model of menopausal insomnia and scientific evaluation to

会议

GABA transporter-1 inhibitor NO-711 alters the EEG power spectra and increases non-rapid eye movemen

GABA transporter subtype 1 (GAT1) constructs high affinity reuptake sites for GABA in the CNS and regulates GABAergic transmission.Compounds that inhibit GAT1 are targets for epilepsy treatment.Sedati

会议

Hypothalamic Regulation of Sleep-wake Cycle,from Basic Research to Drug Discovery

其他学术论文