【摘 要】
：
Titanium-based alloys are commonly used in orthopedic implants because of their desirable mechanical strength,corrosion resistance,and biocompatibility.Bact
【机 构】
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Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials,Ministry-of-Education
【出 处】
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2015 Shanghai Thin Film Conference(2015上海薄膜国际会议)
论文部分内容阅读
Titanium-based alloys are commonly used in orthopedic implants because of their desirable mechanical strength,corrosion resistance,and biocompatibility.Bacterial infection often induces the implant failure.Surface modification is the best way to not only improve the biocompatibility but also enhance the antibacterial performance of metallic implants.In the work,one-dimensional nanostructures including TiO2 nanotube and titanate nanowire were constructed on the surface of Ti alloys.The former prepared by anodization method was used for drug loading with antibacterial polymer sealing while the latter produced by hydrothermal method was employed as carriers for Ag nanoparticles.Drug release tests disclosed that the drug release profile could be tuned to achieve the optimal therapeutic action throughout the treatment time by varying the thickness of the polymer film.SEM and TEM examinations showed that Ag nanoparticals could also be well carried by one dimensional titanate nanowires.Antibacterial tests revealed that the antibacterial activity increased with the increase of initial concentration of silver nitrate solution.
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