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For electrochemical biosensor fabrication,sensitivity and selectivity are two key parameters which are mainly determined by the properties of electrode materials,especially affected by micro-morphology.However,different with other materials,electrochemical biosensing materials should require extra limits such as biocompatibility,mild function conditions which suffer more difficulties in structure control.In this presentation,we will introduce our group work on the development of a series of novel in-situ preparation approaches to push the regular crystallization behaviors of various materials in electrochemical biosensor application.For example,Prussian blue which is widely served as an electron-mediator in oxidase reaction can hardly form its regular structure.Hence,we designed electrostatic self-assembly,aerosol deposition,electric field induced self-assembly and template assisted self-assembly approaches to successfully harvest its nanocube,micro-nano double structures and nano-network morphologies to bring at least twice enhancement of sensitivities to H2O2,glucose,lactate and glutamate.[1-3] Also,an oriented microarray of Ni(en)3Ag2I4 hybrid material was realized by self-assembled monolayers(SAMs)assisted approach to decrease the detection limit to H5N1 virus and Hg2+.[4] Furthermore,a uniform nano-grid of graphene and controllable pore structures of graphene were respectively synthesized to apply in the highly ordered immobilization of protein and detection of cancer labels.[5] As demonstration,biosensing performance will be highly promoted by nanostructure formation.Novel architectures of biosensing films demond more approaches development.In future,we believe that as-developed approaches can be promising in the nanostructure control of more materials in other subjects.