【摘 要】
：
An efficient quinoline-derived fluorescent chemosensor(named QLSA)for the detection of Zn2+ was reported.This sensor was facilely synthesized via a simple l
【机 构】
：
DepartmentofChemistry,TsinghuaUniversity,Beijing,100084,PRChina
【出 处】
：
2016年分析化学前沿国际研讨会及中美分析化学研讨会
论文部分内容阅读
An efficient quinoline-derived fluorescent chemosensor(named QLSA)for the detection of Zn2+ was reported.This sensor was facilely synthesized via a simple linker NH2–NH2 connected quinoline-2-carboxylic acid and salicylaldehyde.QLSA displayed favorable selectivity for Zn2+ over other common metal ions with high sensitivity(the detection limit 21 nM),and lead tosignificant fluorescence OFF–ON switching.In the structure of QLSA,the N atoms of quinoline unit and-CH=N-bond,and the O atom of-OH coordinate the center Zn(II)and form two six-membered rings,which would stabilize the complex.Unlike classical conjugated organic probes with smaller Stokes shift,this chemosensor exhibited a large Stokes shift over 170 nm.The mechanism of the interaction between QLSA and Zn2+ has been investigated via NMR and HRMS analysis.Moreover,further application of this sensor in fluorescence imaging was studied in Hela cell by confocal fluorescence microscopy,suggesting that this chemosensor was proved to be a useful tool for tracking Zn2+ levels in vivo.
其他文献
To achieve the simultaneous capture of various target proteins,the multi-epitope templates imprinted particles were developed by phase inversion-based polye
For bottom-up based proteome analysis,sample preparation including protein extraction,purication and digestion is indispensable prior to LC-MS analysis.Howe
Nitric Oxide(NO)is a significant gaseous signalling molecule in various pathological and physiological pathways,whereas many of its functions are still ambi
Self-assembly of nanoparticles has attracted sustaining interest to build blocks spontaneously organize into ordered structures in the field of nanotechnolo
Nano-gap and nano-tip have been widely exploited for attaining regions of "hot-spot" fields and high SERS(Surface Enhance Raman Scattering)-active substrate
Digital electronics is widely used in daily life especially on demand big data and precision medicine that it is almost impossible to find an electric devic
The determination of folate receptor(FR)that over expressed in most of cancerous cells frequently is significant for the clinical diagnosis and treatment of
Highly and blue light emitting fluorescent carbon dots(C-Dots)were synthesized by a facile and environmentally friendly hydrothermal process using citric ac
3,3,5,5-tetramethylbenzidine(TMB)has been widely used as a chromogenic substrate for colorimetric immunoassays.Normally,the colorless TMB is oxidized into y
In this work,a microfluidic device for kinetic study of oligonucleotide and protein interaction was developed based on a highly selective luminescent switch