【摘 要】
：
Photodynamic therapy(PDT)is an attractive minimal-invasive modality for cancer treatment [1].Upon excitation by light,the tumor-localized photosensitizer generates intracellular reactive oxygen specie
【机 构】
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College of Chemistry,Fuzhou University,Fuzhou 350108,China
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
Photodynamic therapy(PDT)is an attractive minimal-invasive modality for cancer treatment [1].Upon excitation by light,the tumor-localized photosensitizer generates intracellular reactive oxygen species(ROS),particularly singlet oxygen,to cause cancer cells and tissues damage.Tumor-specific activation of photosensitizers is an effective strategy for developing tumor-targeting photosensitizers,which remains a major challenge for photodynamic therapy [2,3].Here we report a novel tumor-pH-responsive nanocomposite(LDH-ZnPcS8),which was prepared through electrostatic interaction between negatively charged octasulfonate-modified zinc(Ⅱ)phthalocyanine(ZnPcS8)and cationic hydroxide layers of layered double hydroxide(LDH)[4,5].
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