Using a silicon based implantable microelectrode array to evaluate striatal dopamine release and neu

来源 :中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议 | 被引量 : 0次 | 上传用户：chinagood111

【摘要】

：

【作者】

：

Lili Yang Yilin Song Guihua Xiao Song Zhang Huiren Xu Shengwei Xu Xinxia Cai

【机构】

：

State Key Laboratory of Transducer Technology,Institute of Electronics,Chinese Academy of Sciences,B

【出处】

：

中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议

【发表日期】

：

2016年5期

【关键词】

：

Implantable MEA Neuroelectrophysiological dopamine DBS Striatum Subthalamic nucl

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　　Subthalamic nucleus deep brain stimulation(STN DBS)ameliorates motor symptoms of Parkinsons disease,but the precise mechanism is still unknown.It may act via eliciting neurotransmitter release.However,the precise relationships between DBS and neurotransmitter release are not established.Microsensors,which exhibit high temporal and spatial resolution,may serve as powerful analytical tools.Here We described a low cost silicon based 16-site implantable microelectrode array(MEA)chip fabricated by standard lithography technology for in vivo electrophysiological and electrochemical dual-mode test.

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