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  5. Both Methotrexate and Gentamicin-Loaded Coating on Bone Implants for Antibacterial and Antitumor App

Both Methotrexate and Gentamicin-Loaded Coating on Bone Implants for Antibacterial and Antitumor App

来源 :中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议 | 被引量 : 0次 | 上传用户：liu748291485wei
【摘 要】
：
En bloc resection and prosthetic replacement are the common methods to treat the malignant bone tumor.However,the bacterial infection and bone tumor metastasis may cause the recurrence of orthopedic i
【作 者】
：
Jinyan Lin Yanmei Zhang Changjian Lin 
【机 构】
：
College of Materials,Department of Chemistry,College of Chemistry and Chemical Engineering,Xiamen Un
【出 处】
：
中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
【发表日期】
：
2016年5期
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　　En bloc resection and prosthetic replacement are the common methods to treat the malignant bone tumor.However,the bacterial infection and bone tumor metastasis may cause the recurrence of orthopedic implants.In this paper,a novel coating on the surface of Ti-based bone implants was developed for restraining osteosarcoma(MG-63 cells)and inhibiting bacteria infection.The dopamine(DA)-modified hyaluronic acid(HA)(designed as HA-DA)was first synthesized and deposited on the corroded Ti substrates to form Ti/HA-DA,then both methotrexate(MTX)and gentamicin(GM)-loading chitosan nanoparticles(designed as CS@MTX+GM NPs)prepared by ionic crosslinking method were electrostatically immobilized onto the surface of Ti/HA-DA(designed as Ti/HA-DA/CS@MTX+GM NPs).
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