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目的观察兰索拉唑、硫糖铝、呋喃唑酮三联疗法对幽门螺杆菌(Hp)的根除效果及对消化性溃疡(PU)的治疗效果。方法对142例幽门螺杆菌阳性的消化性溃疡,随机分为治疗组和对照组。治疗组72例,给予兰索拉唑15mg,每日2次;呋喃唑酮100mg,每日2次;硫糖铝1000mg,每日3次;饭前服用,疗程2周。对照组70例,给予胶体果胶铋100mg,每日3次;硫糖铝1000mg,每日3次;呋喃唑酮100mg,每日2次;饭前服用,疗程2周。停药4周后复查胃镜。结果治疗组与对照组Hp根除率分别为93.9%、53.5%,有显著差异(P<0.05);溃疡愈合率分别为97.22%、77.14%,有显著差异(P<0.05)。结论:兰索拉唑、硫糖铝、呋喃唑酮三联疗法具有疗程短、疗效高,依从性好、治疗中无明显不良反应,值得推广应用。
Objective To observe the eradication effects of lansoprazole, sucralfate and furazolidone triple therapy on Helicobacter pylori (Hp) and the therapeutic effect on peptic ulcer (PU). Methods 142 cases of Helicobacter pylori-positive peptic ulcer were randomly divided into treatment group and control group. The treatment group of 72 patients given lansoprazole 15mg twice daily; furazolidone 100mg twice daily; sucralfate 1000mg three times daily; before taking the medication for 2 weeks. The control group of 70 cases, given colloidal bismuth pectin 100mg, 3 times a day; sucralfate 1000mg, 3 times a day; furazolidone 100mg, 2 times a day; Four weeks after discontinuation of gastroscopy. Results The eradication rates of Hp in the treatment group and the control group were 93.9% and 53.5%, respectively (P <0.05). The healing rates of ulcer were 97.22% and 77.14%, respectively, with significant difference (P <0.05). Conclusion: Lansoprazole, sucralfate, furazolidone triple therapy with short course, high efficacy, good compliance, no obvious adverse reactions in treatment, it is worth popularizing and applying.