论文部分内容阅读
临床及实验研究已证明长春新碱(VCR)可引起血小板增多,在发生血小板增多之前并不会出现血小板减少现象,提示血小板增多并不是由于药物引起的骨髓抑制或血小板破坏造成的反跳现象引起的。VCR引起血小板增多的原因未明。本文作者研究VCR引起血小板增多的机制,着重探讨是否输入正常血小板可以防止VCR引起的巨核细胞生成反应。实验方法;对象为大鼠。分两部份,第一部份将大鼠分4组,分别给予:VCR;VCR+输
Clinical and experimental studies have demonstrated that vincristine (VCR) can cause thrombocytosis, thrombocytopenia does not occur before thrombocytosis phenomenon, suggesting that thrombocytosis is not due to drug-induced bone marrow suppression or platelet damage caused by the rebound phenomenon of. The reason why VCR causes thrombocytosis is unknown. The authors investigated the mechanism of VCR-induced thrombocytopenia and focused on whether megakaryocytopoiesis induced by VCR can be prevented by the administration of normal platelets. Experimental method; the object is rat. Divided into two parts, the first part of the rats were divided into 4 groups, were given: VCR; VCR + lose