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桔酰苯胺即N-(β-二乙氨乙基)-N-邻甲苯基-3′,4′,5′-三甲氧基苯甲酰胺马来酸盐(代号603)是一种有抗心律失常作用的新型化合物。试验证明,对各种心律失常动物模型有一定的预防和治疗作用,治疗指数也较大,现已进入临床试验阶段。关于桔酰苯胺的药代动力学研究报道甚少,体内生物转化尚未阐明。为了解它对药酶的影响,以及在药物代谢上的种属差异,本研究用安替比林血浆半衰期(t(1/2))为指标,用双波长薄层扫描定量测
Anilide, N- (β-diethylaminoethyl) -N-o-tolyl-3 ’, 4’, 5’-trimethoxybenzamide maleate (code 603) New compounds with arrhythmic effects. Experiments show that a variety of arrhythmia animal models have a preventive and therapeutic effect, the treatment index is also larger, has now entered the clinical trial phase. Pharmacokinetics of citanilide is poorly reported, and in vivo biotransformation has not been elucidated. In order to understand its effects on drug enzymes, and the species differences in drug metabolism, this study used antipyretic plasma half-life (t (1/2)) as an indicator, double-wavelength thin layer scanning quantitative measurement