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目的探讨125I种子近距离放射源(125I籽源)在多发性颅内肿瘤中的临床应用。方法采用立体定向的方法将125I籽源置入中枢神经系统实质性恶性肿瘤间,作肿瘤间质内放疗,共46例病人,病人以无法手术的、肿瘤晚期的和手术后复发的脑深部多发性肿瘤和颅内转移瘤为主。结果46例病人随访1年后,28例病人肿瘤大小无明显增大或有部分缩小、液化,10例继续增大,8例死亡;结论125I种子放射源(125I籽源)间质内放疗是一种新的中枢神经系统间质内放疗的方法,从肿瘤内直接杀伤肿瘤细胞,作用明显,对周围脑组织损伤小,且操作简单,副作用小,易为病人接受,适于无法手术的,或位于功能区的,难于手术的脑深部各种肿瘤。
Objective To investigate the clinical application of 125I seed brachytherapy (125I seed) in multiple intracranial tumors. Methods Stereotactic method was used to implant 125I seeds into the malignant tumors of the central nervous system for radiotherapy of interstitial tumors. A total of 46 patients were treated with unresectable, advanced and retroperitoneal brain tumors Sexually transmitted tumors and intracranial metastases. Results After 46 years of follow-up, the tumor size of 28 patients had no obvious increase or some of them were liquefied. Ten patients continued to increase in size and 8 patients died. CONCLUSIONS: 125I seed radioactive source (125I seed) A new method of central nervous system interstitial radiation therapy, tumor cells directly from the tumor, the role of obvious damage to the surrounding brain tissue and small, simple operation, side effects, easy for patients to accept, suitable for inoperable, Or located in the functional area, difficult to operate a variety of deep brain tumors.