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妊娠高血压综合征(简称妊高征)是产科领域的主要问题之一。今就近二年来有关妊高征的研究情况加以归纳: 一、血凝方面的变化 (一)抗凝血酶Ⅲ(ATⅢ)的变化 凝血功能障碍是妊高征患者的重要病理生理变化,Weenink等的正常妊娠组其ATⅢ值均在正常范围。但在先兆子痫患者ATⅢ耗损增加,且其血桨ATⅢ含量和肝肾功能受损情况及母体病率等成相关,特别是ATⅢ值和血小板计数、胎盘梗塞、蛋白尿等均有明显关系。另外,在重症先兆子痫患者体内的ATⅢ含量极端降低,致使肝素对此类患者可不起作用。其病情恶化或好转与ATⅢ的升高或降低有关。ATⅢ可与激活的凝血因子如Xa及凝血酶等作用而形成不可逆的复合物而抑制凝血,先兆子痫患者,ATⅢ的消耗较合成多,故凝血功能受损。
Pregnancy-induced hypertension (PIH) is one of the main problems in the field of obstetrics. This article summarizes the research on PIH in recent two years: I. Changes in Hemolytic Activity (I) Changes in Antithrombin III (ATⅢ) Coagulation dysfunction is an important pathophysiological change in patients with PIH. Weenink et al Of normal pregnancy group AT Ⅲ values are in the normal range. However, AT Ⅲ depletion in preeclampsia patients increased, and the plasma AT Ⅲ content and liver and kidney dysfunction and maternal morbidity and other related, especially the AT Ⅲ value and platelet count, placental infarction, proteinuria and so have a clear relationship. In addition, ATⅢ levels in patients with severe preeclampsia are extremely reduced, rendering heparin irrelevant to such patients. The deterioration or improvement of their condition is related to the increase or decrease of ATⅢ. AT Ⅲ can interact with activated coagulation factors such as Xa and thrombin to form an irreversible complex and inhibit coagulation. In patients with preeclampsia, the consumption of AT III is more than that of AT III, so coagulation is impaired.