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目的掌握洪泽县0～7岁学前儿童的骨碱性磷酸酶(BALP)水平,为合理防治儿童维生素D缺乏提供科学依据。方法对4987名进行健康体检的0～7岁儿童测定其BALP水平。结果①4987名儿童BALP检测异常898例,检出率为18.01%,结合临床症状确诊为维生素D不同程度缺乏的儿童778例,占BALP检测异常的86.63%。②男女儿童BALP异常率差异无统计学意义。③BALP异常检出率随着年龄的增长而降低(P<0.01),维生素D缺乏患病率随年龄增长而呈下降趋势(P<0.01)。结论 BALP水平检测敏感性强,可以作为维生素D缺乏筛查的重要客观参考指标。洪泽地区儿童维生素D缺乏仍然比较严重,应把防治维生素D缺乏作为一个长期的健康保健工作的重点内容。
Objective To understand the level of bone alkaline phosphatase (BALP) in preschool children aged 0 ~ 7 years in Hongze County and provide a scientific basis for the prevention and treatment of vitamin D deficiency in children. Methods 4987 children aged 0 ~ 7 years who had physical examination were tested for BALP level. Results ① There were 898 cases with abnormal BALP in 4987 children, the detection rate was 18.01%, 778 cases of children with different degrees of vitamin D deficiency and 86.63% of the BALP were diagnosed by clinical symptoms. ② There was no significant difference in the abnormal rate of BALP between male and female children. The detection rate of abnormal ALP decreased with age (P <0.01). The prevalence of vitamin D deficiency decreased with age (P <0.01). Conclusion The sensitivity of BALP detection is high and can be used as an important objective reference for the screening of vitamin D deficiency. Hongze children with vitamin D deficiency is still more serious, should be the prevention and treatment of vitamin D deficiency as a long-term focus of health care work.